Portal for life science/healthcare startups
  • Home
    • English Top
    • 日本語トップ
  • Table of Contents (English)
    • Business Setup & Operations >
      • Startup Visa
      • setup corporation, office in Japan
      • Company establishment
      • Life Science Hub, Startup Hub
    • Public Support >
      • List of Public Support Organizations
      • Public Support in Yokohama city
      • Academia-Based Startup Support Guide
      • Mediso free consultation service
    • Regulatory & Compliance >
      • PMDA consultation
      • regulatory considerations when using person infformation
      • Guide to Selecting Regulatory Affairs Staff and Consultants
      • Expedited Review Systems for Pharmaceuticals
      • Guidelines for Establishing Generic Drug Names
      • Combination Products, Combination Medical Devices, Kit Products, Combination Drugs
    • Medical Device, IVD >
      • IVD, LDT, RUO
      • DMAH: Designated Marketing Authorization Holder-Summary Ver.
      • DMAH: Designated Marketing Authorization Holder
      • Combination Products, Combination Medical Devices, Kit Products, Kit Components, Assortment Products
      • How to determine if a product is a medical device
      • medical device classification for combined products
      • medical device class
      • how to confirm JMDN of medical device
      • medical device & IVD reimbursement-Summary Ver.
      • medical device & IVD reimbursemenet
      • insurance reimbursement for SaMD
      • Comparison of Medical Device Definitions: Japan, US, & EU
      • Companion Diagnostics and Gene Panel Testing
    • Pharmaceutical, regenerative medicine >
      • How to determine if a product is a Pharmaceutical Drug
      • Advanced Medical Care System
      • Over-The-Counter (OTC) Drug
      • References on Reimbursement (Cost Calculation) for Regenerative Medical Products
    • Healthcare & Caretech Products >
      • guidance for non medical services
      • Therapeutic Orthoses and Assistive Devices
      • Cosmetics and Quasi-Drugs
      • Overseas Expansion of Non-Medical Device Products as Medical Devices: Learning from the Case of PARO
    • Funding, Partnering & Networking >
      • Utilization of Public Grants and Subsidies
      • J-Ships
      • Partnering
    • Intellectual Property >
      • patent or trade secret?
      • employee invention
      • Matching of Patents Held by Startups and Individuals
    • Legal & Contracts >
      • References for Contracts
      • Guide to Industry-Academia Collaboration Agreements for Academic Researchers
    • Academia & Tech Transfer
    • Licensing, partnering >
      • Introducing Seeds to Pharmaceutical Companies
      • Incentives (Returns) to Licensor Universities
    • References in English
  • コンテンツ一覧
    • 事業設立・運営 >
      • 法人設立
      • ライフサイエンスハブ、スタートアップハブ
    • 公的支援 >
      • 公的支援機関リスト
      • 大学発スタートアップ支援機関・プログラムガイド
      • AMED Medical IP Desk
      • MEDISO活用のススメ
    • 薬事・規制関連 >
      • PMDA RS相談活用のススメ
      • 薬事スタッフ・コンサル選定ガイド
      • 都道府県薬務課一覧
      • コンビネーション製品、組合せ医療機器、キット製品、組合せ医薬品
    • 医薬品、再生医療等製品 >
      • 医薬品の該当性確認方法
      • 医薬品一般的名称設定のガイドライン
      • 医薬品、医療機器等の開発に当たって、参照したい資料
      • 先進医療制度
      • 一般用医薬品(OTC)
      • コンパニオン診断薬と遺伝子パネル検査
      • 再生医療等製品の保険償還(原価計算)に関する参考情報
    • 医療機器、体外診断用医薬品 >
      • 体外診、ラボ開発検査、研究用試薬
      • 医療機器該当性確認ガイド
      • 医療機器と非医療機器の機能が複合した製品は?
      • 医療機器の一般的名称と確認方法
      • 医療機器のクラス分類
      • 医療機器・体外診の保険収載
      • SaMDの保険収載
    • ヘルスケア・ケアテック >
      • 非医療分野の検査サービスを展開する際に注意すべきポイント
      • 治療用装具と補装具
      • 化粧品及び医薬部外品
      • 医療機器とするか、非医療機器とするか
    • 資金調達 >
      • 公的な助成金、補助金の活用
      • 特定投資家向け銘柄制度(J-Ships)
      • パートナリング
      • アカデミア研究者がPIとして応募可能なグラントリスト
      • 海外在住の日本人研究者が日本の助成金を獲得する方法
    • 知的財産 >
      • 特許か?営業秘密か?
      • 職務発明:アカデミア・公的研究機関に所属する研究者が注意すべきポ
      • スタートアップや個人が保有する特許のマッチング
      • ライセンスを受けた大学へのインセンティブ(還元)について
    • 法務・契約 >
      • 契約関連で参考になる公的機関の資料
      • 個人情報を利用する製品開発時の 留意すべき法規制
    • アカデミア、技術移転 >
      • アカデミア研究者のための産学連携契約ガイド
    • ライセンシング、パートナリング >
      • 製薬企業等へのシーズ紹介
    • 海外展開 >
      • 米国展開(主に医療機器)に、読むと役立つ情報リスト
      • 米国FDAにおける、医療機器該当性の確認ステップ
      • 米国における、医療機器の申請データ・試験計画の相談方法((Pre-Submission/Q-Submission
      • 公的機関の海外展開支援
      • 横浜市の公的支援サービス
      • JETROを徹底活用しよう
      • 日米欧での医療機器定義の比較
      • 簡略審査(審査の迅速化)
      • 海外規制等の情報収集
      • 非医療機器製品の海外での医療機器展開
    • オーストラリア >
      • オーストラリア研究開発優遇税制の概要
      • オーストラリア研究開発優遇税制の適用を受けるには
      • オーストラリアでの主要イベント
      • R&D関連の公的機関
      • オーストラリア助成金情報

Company Establishment

Choosing a Corporate Form: Kabushiki Kaisha vs. Godo Kaisha
While startups primarily choose between a "Kabushiki Kaisha" (joint-stock corporation) and a "Godo Kaisha" (limited liability company), establishing a Kabushiki Kaisha is common in the life sciences field, which requires large-scale external fundraising. On the other hand, if you do not plan to raise funds from VCs in the near future, a Godo Kaisha with its simple organizational structure may be a good option. It is also possible to change the company form from a Godo Kaisha to a Kabushiki Kaisha in the future.
  • (Which is better, a Kabushiki Kaisha or a Godo Kaisha?, J-Net21, Organization for Small & Medium Enterprises and Regional Innovation, JAPAN, https://j-net21.smrj.go.jp/startup/manual/list6/6-3-3.html)


​Specific Steps for Establishing a Kabushiki Kaisha
The establishment of a Kabushiki Kaisha proceeds in the following steps. It is also possible to request this process from a professional (such as a judicial scrivener).
  • Determine Basic Matters
    • Decide on the trade name (company name), business objectives, head office location, amount of capital, founder(s), number of shares to be issued, and officer structure.
    • Tip: It is a good idea to include potential future business activities in the business objectives. For businesses that require licenses and permits, it is necessary to state objectives that meet those requirements.
  • Create and Notarize the Articles of Incorporation (Teikan)
    • Create the Articles of Incorporation, which are the fundamental rules of the company.
    • After creation, have them notarized at a notary office. (The 40,000 JPY revenue stamp fee is not required for electronic Articles of Incorporation).
  • Pay in Capital
    • The specified capital is paid into the founder's personal bank account. A copy of the bankbook serves as proof of payment.
  • Prepare Registration Documents
    • Prepare the necessary documents to be submitted to the Legal Affairs Bureau, such as the registration application form, acceptance of office letter, and personal identification documents.
  • Apply for Company Establishment Registration
    • File the application for registration at the Legal Affairs Bureau that has jurisdiction over the head office location. This application date becomes the company's establishment date.
  • Post-Establishment Procedures
    • File the notification of incorporation with the tax office, prefectural tax offices, and pension offices, and complete procedures for social insurance enrollment.
  • (Procedures for Establishing a Kabushiki Kaisha, J-Net21, Organization for Small & Medium Enterprises and Regional Innovation, JAPAN, https://j-net21.smrj.go.jp/startup/manual/list6/6-2-1.html)


Utilizing Public Consultation Services

Specialized knowledge in areas such as accounting, human resources, etc. is essential for establishing a company and its subsequent operations. You should consult with experts and public consultation services before starting your business.

  • Utilize the industry-academia collaboration departments of academia
    • If you are a researcher in academia, you should start by consulting with the industry-academia collaboration department of your institution. You can receive consistent support not only for starting a business, but also for intellectual property, research support, and business matching. By being certified as a startup originating from academia, you will be able to receive even more substantial support.

  • Utilize the Organization for Small & Medium Enterprises and Regional Innovation, JAPAN (SMRJ)
    • If you are not affiliated with academia, it is a good idea to gather information and consult with the SMRJ or the consultation services of local governments.
    • I want to start a business | For those with concerns about starting a business | Organization for Small & Medium Enterprises and Regional Innovation, JAPAN
    • Consultation services for starting a business/entrepreneurship | J-Net21 [SME Business Support Site]

  • Utilize support from local governments
    • Each local government also provides generous support for starting a business. For example, the Tokyo Metropolitan Government provides the "Tokyo Sogyo NET," which offers centralized information on starting a business, and publishes a guidebook summarizing support measures. In addition, Tokyo has the Tokyo One-Stop Business Establishment Center, where you can complete the administrative procedures required for establishing a corporation and starting a business (notarization of articles of incorporation, registration, tax, pension/social insurance) in one place.
    • Tokyo Sogyo NET
    • 202011_tokyoshienguide.pdf
    • Tokyo One-Stop Business Establishment Center | Business Support in Tokyo | Invest Tokyo - Office of the Governor for Policy Planning

Tips
  • An address for corporate registration is required to establish a corporation, but in the early stages, the number of employees may be small, or a large workforce may not be necessary depending on the business model. The key to establishing a corporation with good cost and time performance is to initially use a so-called virtual office.
  • Particularly for startups developing pharmaceuticals or medical devices, it is recommended to establish the corporation within a life science ecosystem. There are co-working spaces within the ecosystem, and related companies and institutions are concentrated there, making business networking much easier. The life science field is highly specialized, and mismatches can occur in various situations within a general startup ecosystem. If it is difficult to establish the corporation within a life science ecosystem, it is a good idea to become a member of one of those ecosystems to gather information separately.
  • ​
@K.Kamitani
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life science hub, startup hub
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About JPRO
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​オフィス概要
​コンテンツ一覧
Ⓒ2025 JPRO
JPRO is a Japan-based business incubator for startups. 
Our approach is unique because our primary focus is on enabling startup self-sufficiency. Our core mission is to help startups optimize their time and cost-efficiency, ensuring they avoid unnecessary expenses and delays. We achieve this by providing centralized access to essential, high quality information—all completely free of charge.
The reliability of our content is exceptionally high, as our information is sourced directly from public institutions and the advice mirrors what we provide in our official advisory roles within these very organizations.
​"You'll likely gain a clear understanding of what needs to be done, enabling you to manage many aspects of your business in-house."
  • Home
    • English Top
    • 日本語トップ
  • Table of Contents (English)
    • Business Setup & Operations >
      • Startup Visa
      • setup corporation, office in Japan
      • Company establishment
      • Life Science Hub, Startup Hub
    • Public Support >
      • List of Public Support Organizations
      • Public Support in Yokohama city
      • Academia-Based Startup Support Guide
      • Mediso free consultation service
    • Regulatory & Compliance >
      • PMDA consultation
      • regulatory considerations when using person infformation
      • Guide to Selecting Regulatory Affairs Staff and Consultants
      • Expedited Review Systems for Pharmaceuticals
      • Guidelines for Establishing Generic Drug Names
      • Combination Products, Combination Medical Devices, Kit Products, Combination Drugs
    • Medical Device, IVD >
      • IVD, LDT, RUO
      • DMAH: Designated Marketing Authorization Holder-Summary Ver.
      • DMAH: Designated Marketing Authorization Holder
      • Combination Products, Combination Medical Devices, Kit Products, Kit Components, Assortment Products
      • How to determine if a product is a medical device
      • medical device classification for combined products
      • medical device class
      • how to confirm JMDN of medical device
      • medical device & IVD reimbursement-Summary Ver.
      • medical device & IVD reimbursemenet
      • insurance reimbursement for SaMD
      • Comparison of Medical Device Definitions: Japan, US, & EU
      • Companion Diagnostics and Gene Panel Testing
    • Pharmaceutical, regenerative medicine >
      • How to determine if a product is a Pharmaceutical Drug
      • Advanced Medical Care System
      • Over-The-Counter (OTC) Drug
      • References on Reimbursement (Cost Calculation) for Regenerative Medical Products
    • Healthcare & Caretech Products >
      • guidance for non medical services
      • Therapeutic Orthoses and Assistive Devices
      • Cosmetics and Quasi-Drugs
      • Overseas Expansion of Non-Medical Device Products as Medical Devices: Learning from the Case of PARO
    • Funding, Partnering & Networking >
      • Utilization of Public Grants and Subsidies
      • J-Ships
      • Partnering
    • Intellectual Property >
      • patent or trade secret?
      • employee invention
      • Matching of Patents Held by Startups and Individuals
    • Legal & Contracts >
      • References for Contracts
      • Guide to Industry-Academia Collaboration Agreements for Academic Researchers
    • Academia & Tech Transfer
    • Licensing, partnering >
      • Introducing Seeds to Pharmaceutical Companies
      • Incentives (Returns) to Licensor Universities
    • References in English
  • コンテンツ一覧
    • 事業設立・運営 >
      • 法人設立
      • ライフサイエンスハブ、スタートアップハブ
    • 公的支援 >
      • 公的支援機関リスト
      • 大学発スタートアップ支援機関・プログラムガイド
      • AMED Medical IP Desk
      • MEDISO活用のススメ
    • 薬事・規制関連 >
      • PMDA RS相談活用のススメ
      • 薬事スタッフ・コンサル選定ガイド
      • 都道府県薬務課一覧
      • コンビネーション製品、組合せ医療機器、キット製品、組合せ医薬品
    • 医薬品、再生医療等製品 >
      • 医薬品の該当性確認方法
      • 医薬品一般的名称設定のガイドライン
      • 医薬品、医療機器等の開発に当たって、参照したい資料
      • 先進医療制度
      • 一般用医薬品(OTC)
      • コンパニオン診断薬と遺伝子パネル検査
      • 再生医療等製品の保険償還(原価計算)に関する参考情報
    • 医療機器、体外診断用医薬品 >
      • 体外診、ラボ開発検査、研究用試薬
      • 医療機器該当性確認ガイド
      • 医療機器と非医療機器の機能が複合した製品は?
      • 医療機器の一般的名称と確認方法
      • 医療機器のクラス分類
      • 医療機器・体外診の保険収載
      • SaMDの保険収載
    • ヘルスケア・ケアテック >
      • 非医療分野の検査サービスを展開する際に注意すべきポイント
      • 治療用装具と補装具
      • 化粧品及び医薬部外品
      • 医療機器とするか、非医療機器とするか
    • 資金調達 >
      • 公的な助成金、補助金の活用
      • 特定投資家向け銘柄制度(J-Ships)
      • パートナリング
      • アカデミア研究者がPIとして応募可能なグラントリスト
      • 海外在住の日本人研究者が日本の助成金を獲得する方法
    • 知的財産 >
      • 特許か?営業秘密か?
      • 職務発明:アカデミア・公的研究機関に所属する研究者が注意すべきポ
      • スタートアップや個人が保有する特許のマッチング
      • ライセンスを受けた大学へのインセンティブ(還元)について
    • 法務・契約 >
      • 契約関連で参考になる公的機関の資料
      • 個人情報を利用する製品開発時の 留意すべき法規制
    • アカデミア、技術移転 >
      • アカデミア研究者のための産学連携契約ガイド
    • ライセンシング、パートナリング >
      • 製薬企業等へのシーズ紹介
    • 海外展開 >
      • 米国展開(主に医療機器)に、読むと役立つ情報リスト
      • 米国FDAにおける、医療機器該当性の確認ステップ
      • 米国における、医療機器の申請データ・試験計画の相談方法((Pre-Submission/Q-Submission
      • 公的機関の海外展開支援
      • 横浜市の公的支援サービス
      • JETROを徹底活用しよう
      • 日米欧での医療機器定義の比較
      • 簡略審査(審査の迅速化)
      • 海外規制等の情報収集
      • 非医療機器製品の海外での医療機器展開
    • オーストラリア >
      • オーストラリア研究開発優遇税制の概要
      • オーストラリア研究開発優遇税制の適用を受けるには
      • オーストラリアでの主要イベント
      • R&D関連の公的機関
      • オーストラリア助成金情報