Portal for life science/healthcare startups
  • Home
    • English Top
    • 日本語トップ
  • Table of Contents (English)
    • Business Setup & Operations >
      • Startup Visa
      • setup corporation, office in Japan
      • Company establishment
      • Life Science Hub, Startup Hub
    • Public Support >
      • List of Public Support Organizations
      • Public Support in Yokohama city
      • Academia-Based Startup Support Guide
      • Mediso free consultation service
    • Regulatory & Compliance >
      • PMDA consultation
      • regulatory considerations when using person infformation
      • Guide to Selecting Regulatory Affairs Staff and Consultants
      • Expedited Review Systems for Pharmaceuticals
      • Guidelines for Establishing Generic Drug Names
      • Combination Products, Combination Medical Devices, Kit Products, Combination Drugs
    • Medical Device, IVD >
      • IVD, LDT, RUO
      • DMAH: Designated Marketing Authorization Holder-Summary Ver.
      • DMAH: Designated Marketing Authorization Holder
      • Combination Products, Combination Medical Devices, Kit Products, Kit Components, Assortment Products
      • How to determine if a product is a medical device
      • medical device classification for combined products
      • medical device class
      • how to confirm JMDN of medical device
      • medical device & IVD reimbursement-Summary Ver.
      • medical device & IVD reimbursemenet
      • insurance reimbursement for SaMD
      • Comparison of Medical Device Definitions: Japan, US, & EU
      • Companion Diagnostics and Gene Panel Testing
    • Pharmaceutical, regenerative medicine >
      • How to determine if a product is a Pharmaceutical Drug
      • Advanced Medical Care System
      • Over-The-Counter (OTC) Drug
      • References on Reimbursement (Cost Calculation) for Regenerative Medical Products
    • Healthcare & Caretech Products >
      • guidance for non medical services
      • Therapeutic Orthoses and Assistive Devices
      • Cosmetics and Quasi-Drugs
      • Overseas Expansion of Non-Medical Device Products as Medical Devices: Learning from the Case of PARO
    • Funding, Partnering & Networking >
      • Utilization of Public Grants and Subsidies
      • J-Ships
      • Partnering
    • Intellectual Property >
      • patent or trade secret?
      • employee invention
      • Matching of Patents Held by Startups and Individuals
    • Legal & Contracts >
      • References for Contracts
      • Guide to Industry-Academia Collaboration Agreements for Academic Researchers
    • Academia & Tech Transfer
    • Licensing, partnering >
      • Introducing Seeds to Pharmaceutical Companies
      • Incentives (Returns) to Licensor Universities
    • References in English
  • コンテンツ一覧
    • 事業設立・運営 >
      • 法人設立
      • ライフサイエンスハブ、スタートアップハブ
    • 公的支援 >
      • 公的支援機関リスト
      • 大学発スタートアップ支援機関・プログラムガイド
      • AMED Medical IP Desk
      • MEDISO活用のススメ
    • 薬事・規制関連 >
      • PMDA RS相談活用のススメ
      • 薬事スタッフ・コンサル選定ガイド
      • 都道府県薬務課一覧
      • コンビネーション製品、組合せ医療機器、キット製品、組合せ医薬品
    • 医薬品、再生医療等製品 >
      • 医薬品の該当性確認方法
      • 医薬品一般的名称設定のガイドライン
      • 医薬品、医療機器等の開発に当たって、参照したい資料
      • 先進医療制度
      • 一般用医薬品(OTC)
      • コンパニオン診断薬と遺伝子パネル検査
      • 再生医療等製品の保険償還(原価計算)に関する参考情報
    • 医療機器、体外診断用医薬品 >
      • 体外診、ラボ開発検査、研究用試薬
      • 医療機器該当性確認ガイド
      • 医療機器と非医療機器の機能が複合した製品は?
      • 医療機器の一般的名称と確認方法
      • 医療機器のクラス分類
      • 医療機器・体外診の保険収載
      • SaMDの保険収載
    • ヘルスケア・ケアテック >
      • 非医療分野の検査サービスを展開する際に注意すべきポイント
      • 治療用装具と補装具
      • 化粧品及び医薬部外品
      • 医療機器とするか、非医療機器とするか
    • 資金調達 >
      • 公的な助成金、補助金の活用
      • 特定投資家向け銘柄制度(J-Ships)
      • パートナリング
      • アカデミア研究者がPIとして応募可能なグラントリスト
      • 海外在住の日本人研究者が日本の助成金を獲得する方法
    • 知的財産 >
      • 特許か?営業秘密か?
      • 職務発明:アカデミア・公的研究機関に所属する研究者が注意すべきポ
      • スタートアップや個人が保有する特許のマッチング
      • ライセンスを受けた大学へのインセンティブ(還元)について
    • 法務・契約 >
      • 契約関連で参考になる公的機関の資料
      • 個人情報を利用する製品開発時の 留意すべき法規制
    • アカデミア、技術移転 >
      • アカデミア研究者のための産学連携契約ガイド
    • ライセンシング、パートナリング >
      • 製薬企業等へのシーズ紹介
    • 海外展開 >
      • 米国展開(主に医療機器)に、読むと役立つ情報リスト
      • 米国FDAにおける、医療機器該当性の確認ステップ
      • 米国における、医療機器の申請データ・試験計画の相談方法((Pre-Submission/Q-Submission
      • 公的機関の海外展開支援
      • 横浜市の公的支援サービス
      • JETROを徹底活用しよう
      • 日米欧での医療機器定義の比較
      • 簡略審査(審査の迅速化)
      • 海外規制等の情報収集
      • 非医療機器製品の海外での医療機器展開
    • オーストラリア >
      • オーストラリア研究開発優遇税制の概要
      • オーストラリア研究開発優遇税制の適用を受けるには
      • オーストラリアでの主要イベント
      • R&D関連の公的機関
      • オーストラリア助成金情報

Incentives (Returns) to Licensor Universities

Academics and researchers often establish startups and receive intellectual property (IP) transferred or licensed from the university. This time, we will consider the topic of incentives (returns) to universities that have granted an IP license.
​
  • Employee Invention
    • In the case of academics and researchers, their inventions are mostly classified as employee inventions under work regulations, and the rights holder is almost always the affiliated institution. First, please confirm the work or IP regulations of your affiliated institution.
    • shokumuhatsumeiseido.pdf
  • IP Licensing
    • To enable a startup (SU) to use intellectual property, such as patents, held by a university, the university transfers or leases (licenses) the rights to the corresponding IP to the SU.
    • Consideration can be paid in cash, or by granting shares or stock options. The recent trend is an increase in the granting of stock options, following the lead of the US and Europe.
      • uni-ven-v2_2-license_chikujouari.pdf
  • Definition of Terms
    • Various terms are used regarding IP licensing, but it is good to understand "license fee" and "royalty." However, there are actually other names, and "license fee" and "royalty" are sometimes used interchangeably, so let's stick to the general usage. The important thing is to decide how much to allocate to the university as consideration for the license, and to always clearly define the terms in the contract so that the contracting parties do not misunderstand each other.
  • License Fee
    • Definition: Simply put, it is a usage fee. It primarily covers IP, but can also cover products or technology. Characteristics:
      • Often a lump-sum payment (upfront fee).
      • May include milestone payments, which are paid based on development progress.
        • Milestone Fee: An additional fee paid when the development of the technology or patent licensed from the university reaches a "specific milestone" defined in the contract.
      • Not directly linked to product sales.
      • The rate changes depending on whether the license is exclusive (exclusive license) or non-exclusive (non-exclusive license).
    • Purpose: Consideration for granting rights, proof of contract establishment, and risk recovery for the university.
    • Case Study: Yale University Startup Licenses
      • Yale adopts a special license for startups that includes a lump-sum payment at the time of the license agreement, plus the university acquiring company shares (equivalent to 3-5%) as an incentive. Therefore, milestone fees and royalties are not set, and the structure is completed with the grant of rights and stock acquisition upon contract signing. Yale Startup Licenses | Yale Ventures
    • "Consideration for License"
      • Although very abstract, it means comprehensive consideration and may include royalties as well as license fees.
    • "Implementation Fee" (Jisshi-ryo)
      • This is the usage fee for a patent. In English, it is called a license fee, but the "implementation rate" used in Japan is limited to IP, mainly patents. This is a term derived from the right to work (jisshi-ken) found in intellectual property law.
      • For reference, data on implementation fee rates for patent rights is available from METI. Although the document refers to it as the royalty rate, since the subject is limited to intellectual property, it can be read as the implementation fee rate. The average for biotechnology is the highest at 6.2%. Research Report on the Value Assessment and Utilization of Patents, etc., Based on Intellectual Property Valuation - Actual Status of Intellectual Property (Asset) Value and Royalty Rates - (METI/Ministry of Economy, Trade and Industry)
  • Royalty
    • Definition: Compensation paid based on sales or profit when products are sold using the licensed patent or technology. When paid continuously based on sales, it is called a running royalty.
    • The royalty may be passed through to the university, even on the sales of a sublicensee.
    • Purpose: A mechanism for the university to gain revenue based on the successful commercialization of the technology.
    • In the biopharma sector, approximately 86% of license agreements include milestone payments, and over 65% include sales-based royalties. Many agreements adopt a complex structure of Upfront payment at contract signing + milestone fees at each stage of development, approval, and commercialization + royalties after market launch. A formula for drug licensing deals
    • On the other hand, some deals may not set royalties and only include a license fee. For example, when an SU purchases the patent from the university in a lump sum, a license agreement for a certain period of software use, or when it is included in the license fee because management is cumbersome.
  • Royalty Rate
    • 25% Rule
      • There is a principle called the 25% Rule, or the Goldscheider Rule. This is a payment of 25% of the product's "operating profit" as a royalty.
      • This is based purely on empirical rules and has been denied in past case law, stating that "it is not rational because the profit margin differs for each product" (Uniloc USA, Inc. v. Microsoft Corp. (January 4, 2011 judgment)).
      • Currently, the Georgia-Pacific Factors, etc., are used in calculating damages for infringement, but since these are originally used for calculating damages, let's keep them as a reference.
    • References
      • Private research companies and non-profit organizations have databases of past deal examples for royalty rates.
      • LES Royalty Rates and Deal Terms Surveys - Licensing Executives Society (LES), 2024_Royalty_Rate_&_Deal_Terms_Executive_Summary.pdf
      • In such documents, the sales-based rate is set higher as the phase progresses:
        • Early Stage: 1% - 3% Basic research or non-clinical stage. The road to commercialization is long and the risk is high, so the licensor's share is set low.
        • Phase I / II: 3% - 8% The stage where human safety and efficacy begin to be confirmed. Most licenses are concluded here, which becomes the market standard.
        • Phase III / Marketed: 8% - 15% Just before or after approval. The investment risk is low and revenue is certain, so the rate jumps up.
    • Basis
      • The basis on which the royalty rate is applied varies widely in practice, such as sales, operating profit, or net profit. By considering the balance of power with the counterparty and the SU's own development efforts, the adjustment can be made not only with the royalty rate but also with what the basis will be.
  • Sublicense
    • Meaning: The licensed company (SU) re-licenses the right to a third party.
    • Image: University → SU → Major Company (Sublicensee)
    • Key Point: The university often contracts to receive a portion of the sublicense income.
  • Three Structures for Sublicense Income Distribution
    • There are mainly three methods for distributing sublicense income, and these may be used alone or in combination.
      • Defining Sublicense Income To Avoid Problems Down The Road - Licensing Executives Society International
    • Allocation
      • A fixed percentage of all payments received from the sublicensee is distributed to the university.
      • Advantage: Simple and less prone to abuse.
      • Disadvantage: Difficult to set the percentage, balancing technology value and investment value is a challenge.
    • Tiered Allocation
      • Different percentages are set before and after commercialization.
      • Advantage: Supports the licensee's fundraising in the early stages and suppresses dilution.
      • Disadvantage: Requires complex negotiation.
    • Pass-Through
      • Royalties based on the sublicensee's sales are passed on to the university.
      • Issue: The university's share may decrease depending on the royalty rate setting.
  • University Distribution of Sublicense Income
    • It is standard for "10% to 25%" of the revenue (upfront payment, milestone) received by the startup to be distributed (returned) to the university. Furthermore, a step-down mechanism (sliding scale) may be introduced where "the distribution rate to the university decreases as the startup takes on development risk and advances the phase."
    • Case 1: Cornell University FastTrack License
      • The principle is 25%, but it is reduced to 15% after obtaining "Approval/Certification."
      • FastTrack for Medical Device and Selected Life Science Technology - Center For Technology Licensing
    • Case 2: Yale University Yale Startup License
      • Initially 20%, but reduced to 10% after "4 years have passed."
      • Yale Startup Licenses | Yale Ventures
  • Regulations, etc., Regarding Returns at Japanese Universities
    • Kyushu University
      • Has established guidelines for reducing or deferring license consideration (upfront payment, implementation fee) for early-stage ventures. https://airimaq.kyushu-u.ac.jp/_cms_dir/uploads/2022/08/venture_guideline.pdf
    • Kyoto University
      • Has established regulations that permit payment in "shares (stock options)" when cash payment is difficult. Kyoto University Regulations on the Handling of Shares, etc., Acquired as Consideration for Licenses, etc.

Licensing agreements are the lifeline of a startup (SU). It is recommended to involve an attorney familiar with life science licensing from before negotiations begin.
employee invention
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Ⓒ2025 JPRO
JPRO is a Japan-based business incubator for startups. 
Our approach is unique because our primary focus is on enabling startup self-sufficiency. Our core mission is to help startups optimize their time and cost-efficiency, ensuring they avoid unnecessary expenses and delays. We achieve this by providing centralized access to essential, high quality information—all completely free of charge.
The reliability of our content is exceptionally high, as our information is sourced directly from public institutions and the advice mirrors what we provide in our official advisory roles within these very organizations.
​"You'll likely gain a clear understanding of what needs to be done, enabling you to manage many aspects of your business in-house."
  • Home
    • English Top
    • 日本語トップ
  • Table of Contents (English)
    • Business Setup & Operations >
      • Startup Visa
      • setup corporation, office in Japan
      • Company establishment
      • Life Science Hub, Startup Hub
    • Public Support >
      • List of Public Support Organizations
      • Public Support in Yokohama city
      • Academia-Based Startup Support Guide
      • Mediso free consultation service
    • Regulatory & Compliance >
      • PMDA consultation
      • regulatory considerations when using person infformation
      • Guide to Selecting Regulatory Affairs Staff and Consultants
      • Expedited Review Systems for Pharmaceuticals
      • Guidelines for Establishing Generic Drug Names
      • Combination Products, Combination Medical Devices, Kit Products, Combination Drugs
    • Medical Device, IVD >
      • IVD, LDT, RUO
      • DMAH: Designated Marketing Authorization Holder-Summary Ver.
      • DMAH: Designated Marketing Authorization Holder
      • Combination Products, Combination Medical Devices, Kit Products, Kit Components, Assortment Products
      • How to determine if a product is a medical device
      • medical device classification for combined products
      • medical device class
      • how to confirm JMDN of medical device
      • medical device & IVD reimbursement-Summary Ver.
      • medical device & IVD reimbursemenet
      • insurance reimbursement for SaMD
      • Comparison of Medical Device Definitions: Japan, US, & EU
      • Companion Diagnostics and Gene Panel Testing
    • Pharmaceutical, regenerative medicine >
      • How to determine if a product is a Pharmaceutical Drug
      • Advanced Medical Care System
      • Over-The-Counter (OTC) Drug
      • References on Reimbursement (Cost Calculation) for Regenerative Medical Products
    • Healthcare & Caretech Products >
      • guidance for non medical services
      • Therapeutic Orthoses and Assistive Devices
      • Cosmetics and Quasi-Drugs
      • Overseas Expansion of Non-Medical Device Products as Medical Devices: Learning from the Case of PARO
    • Funding, Partnering & Networking >
      • Utilization of Public Grants and Subsidies
      • J-Ships
      • Partnering
    • Intellectual Property >
      • patent or trade secret?
      • employee invention
      • Matching of Patents Held by Startups and Individuals
    • Legal & Contracts >
      • References for Contracts
      • Guide to Industry-Academia Collaboration Agreements for Academic Researchers
    • Academia & Tech Transfer
    • Licensing, partnering >
      • Introducing Seeds to Pharmaceutical Companies
      • Incentives (Returns) to Licensor Universities
    • References in English
  • コンテンツ一覧
    • 事業設立・運営 >
      • 法人設立
      • ライフサイエンスハブ、スタートアップハブ
    • 公的支援 >
      • 公的支援機関リスト
      • 大学発スタートアップ支援機関・プログラムガイド
      • AMED Medical IP Desk
      • MEDISO活用のススメ
    • 薬事・規制関連 >
      • PMDA RS相談活用のススメ
      • 薬事スタッフ・コンサル選定ガイド
      • 都道府県薬務課一覧
      • コンビネーション製品、組合せ医療機器、キット製品、組合せ医薬品
    • 医薬品、再生医療等製品 >
      • 医薬品の該当性確認方法
      • 医薬品一般的名称設定のガイドライン
      • 医薬品、医療機器等の開発に当たって、参照したい資料
      • 先進医療制度
      • 一般用医薬品(OTC)
      • コンパニオン診断薬と遺伝子パネル検査
      • 再生医療等製品の保険償還(原価計算)に関する参考情報
    • 医療機器、体外診断用医薬品 >
      • 体外診、ラボ開発検査、研究用試薬
      • 医療機器該当性確認ガイド
      • 医療機器と非医療機器の機能が複合した製品は?
      • 医療機器の一般的名称と確認方法
      • 医療機器のクラス分類
      • 医療機器・体外診の保険収載
      • SaMDの保険収載
    • ヘルスケア・ケアテック >
      • 非医療分野の検査サービスを展開する際に注意すべきポイント
      • 治療用装具と補装具
      • 化粧品及び医薬部外品
      • 医療機器とするか、非医療機器とするか
    • 資金調達 >
      • 公的な助成金、補助金の活用
      • 特定投資家向け銘柄制度(J-Ships)
      • パートナリング
      • アカデミア研究者がPIとして応募可能なグラントリスト
      • 海外在住の日本人研究者が日本の助成金を獲得する方法
    • 知的財産 >
      • 特許か?営業秘密か?
      • 職務発明:アカデミア・公的研究機関に所属する研究者が注意すべきポ
      • スタートアップや個人が保有する特許のマッチング
      • ライセンスを受けた大学へのインセンティブ(還元)について
    • 法務・契約 >
      • 契約関連で参考になる公的機関の資料
      • 個人情報を利用する製品開発時の 留意すべき法規制
    • アカデミア、技術移転 >
      • アカデミア研究者のための産学連携契約ガイド
    • ライセンシング、パートナリング >
      • 製薬企業等へのシーズ紹介
    • 海外展開 >
      • 米国展開(主に医療機器)に、読むと役立つ情報リスト
      • 米国FDAにおける、医療機器該当性の確認ステップ
      • 米国における、医療機器の申請データ・試験計画の相談方法((Pre-Submission/Q-Submission
      • 公的機関の海外展開支援
      • 横浜市の公的支援サービス
      • JETROを徹底活用しよう
      • 日米欧での医療機器定義の比較
      • 簡略審査(審査の迅速化)
      • 海外規制等の情報収集
      • 非医療機器製品の海外での医療機器展開
    • オーストラリア >
      • オーストラリア研究開発優遇税制の概要
      • オーストラリア研究開発優遇税制の適用を受けるには
      • オーストラリアでの主要イベント
      • R&D関連の公的機関
      • オーストラリア助成金情報